Document Detail

Endocarditis caused by Rhodotorula successfully treated with 5-fluorocytosine.
MedLine Citation:
PMID:  1167783     Owner:  NLM     Status:  MEDLINE    
A 7-year-old boy suffering from aortic regurgitation and mitral stenosis and regurgitation was admitted with endocarditis caused by Rhodotorula pilimanae and was treated successfully with orally administered antifungal agent, namely 5-fluorocytosine (5-FC). A dose of 100 mg per kg body weight, divided into four equal parts, was prescribed. After a prolonged febrile period his temperature dropped to normal on the fourth day of 5-FC therapy. Review of the published reports disclosed few cases of endocarditis due to Rhodotorula spp. and this case seems to be the first treated with 5-FC. Follow-up in one year, after discharge from the hospital, revealed no evidence of relapse.
Y Naveh; A Friedman; D Merzbach; N Hashman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  37     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  101-4     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Antifungal Agents / therapeutic use
Aortic Valve Insufficiency / complications
Candidiasis / drug therapy*
Cytosine / administration & dosage,  analogs & derivatives*
Endocarditis / complications,  drug therapy*
Flucytosine / therapeutic use*
Leukocyte Count
Mitosporic Fungi / pathogenicity
Mitral Valve Insufficiency / complications
Mitral Valve Stenosis / complications
Reg. No./Substance:
0/Antifungal Agents; 2022-85-7/Flucytosine; 71-30-7/Cytosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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