Document Detail

Endocardial tears and rupture tracts of left ventricular ruptures during acute myocardial infarction: an autopsy study of 50 out-of-hospital sudden death cases.
MedLine Citation:
PMID:  17045419     Owner:  NLM     Status:  MEDLINE    
We pathologically evaluated endocardial tears and rupture tracts of left ventricular ruptures during acute myocardial infarctions (50 sudden out-of-hospital death cases; 28 men and 22 women; age range 42-88 years; mean age 68.4 years). Endocardial tears were frequently seen at or near the base of the papillary muscles (54%) or in the area where the septum meets the free wall (42%). The endocardial tear was longer in the adjacent septum (mean 2.1+/-1.0cm) than at the papillary muscle base (mean 1.0+/-0.8cm). Accessory tears were observed near the main endocardial tear in about half of the cases (44%). The rupture tract was located well within the infarcted area in 88% and at the border of the infarcted and normal myocardium in 12%. Mature fresh thrombus was found on most main endocardial tears. In most rupture tracts, the thrombus was more mature in the subendocardial than in the subepicardial zone. Morphologically, this study confirmed that most cardiac ruptures start with an endocardial tear at or near the base of the papillary muscles or in the area where the septum meets the free wall, and rapidly progress independent of the histopathologic age of the infarction.
Aya Takada; Kazuyuki Saito; Tatsuya Murai; Akihiko Hamamatsu
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Publication Detail:
Type:  Journal Article     Date:  2006-10-11
Journal Detail:
Title:  Pathology, research and practice     Volume:  202     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  857-62     Citation Subset:  IM    
Department of Forensic Medicine, Saitama Medical University, Moro-Hongo 38, Moroyama, Saitama 350-0495, Japan.
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MeSH Terms
Aged, 80 and over
Death, Sudden / etiology,  pathology*
Endocardium / pathology*
Heart Rupture, Post-Infarction / etiology,  pathology*
Heart Ventricles / pathology
Middle Aged
Myocardial Infarction / complications,  pathology*

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