Document Detail


Endocardial mapping of ventricular tachycardia in one-day-old myocardial infarction.
MedLine Citation:
PMID:  3702039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endocardial mapping of ventricular tachycardia (VT) was performed in one-day-old myocardial infarction using a matrix electrode (6 X 7 = 42) placed on the endocardial surface of the perfused isolated canine heart. Spontaneous focal VT was observed in all 7 dogs. It was neither affected nor terminated by electrical stimulation. Focal VT was induced in 5 dogs by constant pacing or premature programmed stimulation of the main left bundle. It was terminated by electrical stimulation and induction of the VT was suppressed by verapamil (5 X 10(-7)). Endocardial mapping of the spontaneous focal VT and induced focal VT showed initiation of activation from the surviving Purkinje fiber in the infarcted or border zone with subsequent circular expansion of excitation. Reentrant VT was induced in 3 dogs by bursts of rapid pacing and deteriorated into ventricular fibrillation. Endocardial mapping showed a continuous arc of functional conduction block and slowly circulating activation front around the block. It is suggested that in experimental one-day-old myocardial infarction VT resulted from abnormal automaticity and triggered activity in the surviving Purkinje fiber and reentry in the subendocardial muscle layer.
Authors:
T Ohta; J Toyama; M Hirai; T Osaka; I Kodama; K Yamada
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  50     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-06-09     Completed Date:  1986-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electric Stimulation
Electrodes
Endocardium / physiopathology
Heart Conduction System / physiopathology*
Myocardial Infarction / physiopathology*
Purkinje Fibers / physiopathology
Tachycardia / etiology*
Verapamil / pharmacology
Chemical
Reg. No./Substance:
52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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