| Endocardial, intramural, and epicardial activation patterns during sustained monomorphic ventricular tachycardia in late canine myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 3594759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thirteen dogs in whom at least one morphologically distinct sustained ventricular tachycardia (VT) could be reproducibly initiated by programmed cardiac stimulation 18 +/- 3 days following experimental myocardial infarction were placed on total cardiopulmonary bypass for detailed study of the endocardial and epicardial activation during VT under hemodynamically stable conditions. Thirteen morphologically distinct monomorphic VTs were investigated by simultaneous epicardial, endocardial, and intramural bipolar recordings. Local electrograms were used to generate computer-assisted isochronous-activation sequence maps. A complete reentry circuit could be mapped on the epicardial surface in 4 animals and on the endocardial surface in one other animal. In the remaining 8 animals, there was a gap period lasting 43-62 msec in the cardiac cycle during which no endocardial or epicardial activity was observed. In 6 of the 8 animals, bipolar intramural recordings from sites closely associated with regions of endocardial and epicardial conduction block showed intramural activity progressing slowly during the gap period. In these 6 animals, a reentry circuit could be completed by incorporating the local electrograms recorded from the intramural sites. VT could be reproducibly terminated by selectively rendering only these intramural sites refractory by critically timed extrastimuli that failed to result in global ventricular capture. VT could be terminated by epicardial cooling in 2 of the 4 animals with epicardial reentry. By contrast, epicardial cryoablation did not effect intramural reentry and failed to interrupt VT. In this study, intramural pathways constituted an integral part of the reentry circuit in a large proportion of the VTs. |
| | |
Authors:
|
H Garan; J T Fallon; S Rosenthal; J N Ruskin |
Related Documents
:
|
9844249 - Normalization of respiratory sinus arrhythmia by factoring in tidal volume. 6485829 - Role of airway resistance in the control of ventilation during exercise. 1906429 - Physiological dead space & arterial to end-tidal co2 difference under controlled normoc... 2010409 - Respiratory adaptations to dead space loading during maximal incremental exercise. 8153449 - Does peak inspiratory flow contribute to setting vo2max? a test of symmorphosis. 10066699 - Breathing responses to small inspiratory threshold loads in humans. 22975529 - Vitamin d in exercise: physiologic and analytical concerns. 14598189 - Heredity and pituitary response to exercise-related stress in trained men. 7433339 - Effect of propranolol and labetalol on renal haemodynamics at rest and during exercise ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 60 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1987 Jun |
Date Detail:
|
Created Date: 1987-08-21 Completed Date: 1987-08-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 879-96 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Pacing, Artificial Dogs Electric Stimulation Electroencephalography* Electrophysiology Endocardium / physiopathology* Freezing Heart Ventricles / physiopathology Myocardial Infarction / physiopathology* Pericardium / physiopathology* Tachycardia / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
|
R0L HL 25992-01A1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myogenic vasoregulation overrides local metabolic control in resting rat skeletal muscle.
Next Document: Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits.