Document Detail


Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease.
MedLine Citation:
PMID:  22679138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and developmentally plastic mesenchymal cells. All cells in the heart arise from one or more EMTs. Endocardial and epicardial EMTs produce most of the noncardiomyocyte lineages of the mature heart. Endocardial EMT generates valve progenitor cells and is necessary for formation of the cardiac valves and for complete cardiac septation. Epicardial EMT is required for myocardial growth and coronary vessel formation, and it generates cardiac fibroblasts, vascular smooth muscle cells, a subset of coronary endothelial cells, and possibly a subset of cardiomyocytes. Emerging studies suggest that these developmental mechanisms are redeployed in adult heart valve disease, in cardiac fibrosis, and in myocardial responses to ischemic injury. Redirection and amplification of disease-related EMTs offer potential new therapeutic strategies and approaches for treatment of heart disease. Here, we review the role and molecular regulation of endocardial and epicardial EMT in fetal heart development, and we summarize key literature implicating reactivation of endocardial and epicardial EMT in adult heart disease.
Authors:
Alexander von Gise; William T Pu
Related Documents :
23197668 - Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial...
11999658 - Left atrial thrombus causing pulmonary embolism by passing through an atrial septal def...
16866028 - Multicentric cardiac myxoma treated with extended surgery.
17669518 - Revelation of left atrial myxoma during acute myocardial infarction.
7451568 - Improved surgical treatment of tricuspid insufficiency in combined valvular diseases.
7193168 - Use of provocative testing in angina pectoris.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  110     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-08-13     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1628-45     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Endocardium / cytology,  physiology*
Epithelial Cells / cytology,  physiology
Epithelial-Mesenchymal Transition / physiology*
Heart / embryology,  growth & development*
Heart Diseases / pathology,  physiopathology*
Humans
Pericardium / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
HL094683/HL/NHLBI NIH HHS; R01 HL094683/HL/NHLBI NIH HHS; U01 HL100401/HL/NHLBI NIH HHS; U01 HL100401/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of Statin Use Before the Onset of Acute Myocardial Infarction on Coronary Plaque Morphology o...
Next Document:  Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome.