Document Detail

Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling.
MedLine Citation:
PMID:  23178125     Owner:  NLM     Status:  MEDLINE    
The origins and developmental mechanisms of coronary arteries are incompletely understood. We show here by fate mapping, clonal analysis, and immunohistochemistry that endocardial cells generate the endothelium of coronary arteries. Dye tracking, live imaging, and tissue transplantation also revealed that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic and form coronary endothelial networks. Myocardial Vegf-a or endocardial Vegfr-2 deletion inhibited coronary angiogenesis and arterial formation by ventricular endocardial cells. In contrast, lineage and knockout studies showed that endocardial cells make a small contribution to the coronary veins, the formation of which is independent of myocardial-to-endocardial Vegf signaling. Thus, contrary to the current view of a common source for the coronary vessels, our findings indicate that the coronary arteries and veins have distinct origins and are formed by different mechanisms. This information may help develop better cell therapies for coronary artery disease.
Bingruo Wu; Zheng Zhang; Wendy Lui; Xiangjian Chen; Yidong Wang; Alyssa A Chamberlain; Ricardo A Moreno-Rodriguez; Roger R Markwald; Brian P O'Rourke; David J Sharp; Deyou Zheng; Jack Lenz; H Scott Baldwin; Ching-Pin Chang; Bin Zhou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell     Volume:  151     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-01-24     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-96     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Cell Differentiation
Coronary Vessels / cytology,  embryology*,  metabolism
Endothelial Cells / cytology*,  metabolism
Myocardium / cytology*,  metabolism
NFATC Transcription Factors / metabolism
Neovascularization, Physiologic*
Signal Transduction*
Vascular Endothelial Growth Factor A / metabolism*
Vascular Endothelial Growth Factor Receptor-2 / metabolism*
Grant Support
Reg. No./Substance:
0/NFATC Transcription Factors; 0/Nfatc1 protein, mouse; 0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, mouse; EC Endothelial Growth Factor Receptor-2
Comment In:
Cell. 2012 Nov 21;151(5):932-4   [PMID:  23178115 ]

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