| Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. | |
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MedLine Citation:
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PMID: 23178125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The origins and developmental mechanisms of coronary arteries are incompletely understood. We show here by fate mapping, clonal analysis, and immunohistochemistry that endocardial cells generate the endothelium of coronary arteries. Dye tracking, live imaging, and tissue transplantation also revealed that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic and form coronary endothelial networks. Myocardial Vegf-a or endocardial Vegfr-2 deletion inhibited coronary angiogenesis and arterial formation by ventricular endocardial cells. In contrast, lineage and knockout studies showed that endocardial cells make a small contribution to the coronary veins, the formation of which is independent of myocardial-to-endocardial Vegf signaling. Thus, contrary to the current view of a common source for the coronary vessels, our findings indicate that the coronary arteries and veins have distinct origins and are formed by different mechanisms. This information may help develop better cell therapies for coronary artery disease. |
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Authors:
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Bingruo Wu; Zheng Zhang; Wendy Lui; Xiangjian Chen; Yidong Wang; Alyssa A Chamberlain; Ricardo A Moreno-Rodriguez; Roger R Markwald; Brian P O'Rourke; David J Sharp; Deyou Zheng; Jack Lenz; H Scott Baldwin; Ching-Pin Chang; Bin Zhou |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Cell Volume: 151 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-26 Completed Date: 2013-01-24 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1083-96 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Coronary Vessels / cytology, embryology*, metabolism Endothelial Cells / cytology*, metabolism Mice Myocardium / cytology*, metabolism NFATC Transcription Factors / metabolism Neovascularization, Physiologic* Signal Transduction* Vascular Endothelial Growth Factor A / metabolism* Vascular Endothelial Growth Factor Receptor-2 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL078881/HL/NHLBI NIH HHS; HL100398/HL/NHLBI NIH HHS; HL85345/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/NFATC Transcription Factors; 0/Nfatc1 protein, mouse; 0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, mouse; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
| Comments/Corrections | |
Comment In:
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Cell. 2012 Nov 21;151(5):932-4
[PMID:
23178115
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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