| Endocannabinoids and voluntary activity in mice: runner's high and long-term consequences in emotional behaviors. | |
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MedLine Citation:
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PMID: 20353785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endocannabinoid system participates in the regulation of physical activity, although its role is not yet fully understood. Here, we highlight the impact of endocannabinoid signalling on voluntary wheel running in mice and discuss potential mechanisms involved such as hippocampal neurogenesis. Running-induced short-term and long-term alterations of emotional behaviors are scrutinized with regard to the question how endocannabinoids might be involved. While endocannabinoids seem to contribute to the motivational aspects of voluntary running in rodents, influencing the total distance covered most likely via CB1 receptors, they are less involved in the long-term changes of emotional behavior induced by voluntary exercise. |
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Authors:
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Johannes Fuss; Peter Gass |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-29 |
Journal Detail:
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Title: Experimental neurology Volume: 224 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 103-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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RG Behavioral Biology, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health (ZI), University of Heidelberg, Mannheim, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Emotions / physiology* Endocannabinoids / metabolism* Hippocampus / metabolism Mice Motor Activity / physiology* Neurogenesis / physiology Neuronal Plasticity / physiology Neurons / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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