| Endocannabinoids and pregnancy. | |
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MedLine Citation:
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PMID: 20302856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively referred to as the "endocannabinoid system (ECS)". Poorly defined cellular and molecular mechanisms control the biological actions of the ECS. Over the last decade evidence has been emerging to suggest that the ECS plays a significant role in various aspects of human reproduction. In this review, we summarize our current understanding of this role especially the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction. Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed. |
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Authors:
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Anthony H Taylor; Akwasi A Amoako; Katerina Bambang; Tulay Karasu; Alpha Gebeh; Patricia M W Lam; Timothy H Marzcylo; Justin C Konje |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-17 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 921-30 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Reproductive Sciences Section, University of Leicester, Leicester, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / metabolism, physiology Embryo Implantation / physiology Employment Endocannabinoids / metabolism* Female Gametogenesis Humans Placenta / metabolism, physiology Pregnancy / immunology, metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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