Document Detail


Endocannabinoids and pregnancy.
MedLine Citation:
PMID:  20302856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively referred to as the "endocannabinoid system (ECS)". Poorly defined cellular and molecular mechanisms control the biological actions of the ECS. Over the last decade evidence has been emerging to suggest that the ECS plays a significant role in various aspects of human reproduction. In this review, we summarize our current understanding of this role especially the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction. Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed.
Authors:
Anthony H Taylor; Akwasi A Amoako; Katerina Bambang; Tulay Karasu; Alpha Gebeh; Patricia M W Lam; Timothy H Marzcylo; Justin C Konje
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-17
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-30     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  921-30     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / metabolism,  physiology
Cannabinoid Receptor Modulators / metabolism*
Embryo Implantation / physiology
Employment
Endocannabinoids*
Female
Gametogenesis
Humans
Placenta / metabolism,  physiology
Pregnancy / immunology,  metabolism*,  physiology
Grant Support
ID/Acronym/Agency:
G0801523//Medical Research Council
Chemical
Reg. No./Substance:
0/Cannabinoid Receptor Modulators; 0/Endocannabinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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