Document Detail

Endocannabinoids and liver disease. V. endocannabinoids as mediators of vascular and cardiac abnormalities in cirrhosis.
MedLine Citation:
PMID:  18703639     Owner:  NLM     Status:  MEDLINE    
Cirrhosis is associated with marked cardiovascular disturbances. These include hyperdynamic circulation characterized by reduced peripheral vascular resistance and mean arterial pressure and increased cardiac output. Despite the baseline increase in cardiac output, ventricular responsiveness to stimuli is blunted. A number of cellular signaling pathways have been shown to contribute to these abnormalities, including central nervous system cardiovascular dysregulation and humoral factors such as nitric oxide. Endogenous and exogenous cannabinoids have significant cardiovascular effects. Recent evidence suggests that increased activity of the endocannabinoid system at multiple levels contributes to development of both cardiac and vascular changes in cirrhosis. This brief review surveys recent in vivo and in vitro findings in an attempt to highlight the areas of agreement and areas of controversy in the field. The endocannabinoid system affects key cardiovascular regulators, including the autonomic nervous system, cardiac muscle, and vascular smooth muscle. The interplay among these modes of action further complicates interpretation of the in vivo findings. The broad range of cardiovascular actions of endocannabinoids provides ample opportunities for pharmacological manipulation. At the same time, it increases the possibility of undesirable side effects, which need to be carefully evaluated in long-term studies.
Leila Moezi; Seyed Ali Gaskari; Samuel S Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-14
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  295     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G649-53     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Arachidonic Acids / pharmacology,  physiology
Cardiovascular Diseases / etiology*
Endocannabinoids / physiology*
Liver Cirrhosis / complications*,  physiopathology
Polyunsaturated Alkamides / pharmacology
Receptors, Cannabinoid / physiology
Splanchnic Circulation / drug effects,  physiology
TRPV Cation Channels / physiology
Reg. No./Substance:
0/Arachidonic Acids; 0/Endocannabinoids; 0/Polyunsaturated Alkamides; 0/Receptors, Cannabinoid; 0/TRPV Cation Channels; 94421-68-8/anandamide

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