Document Detail

Endocannabinoids and food consumption: comparisons with benzodiazepine and opioid palatability-dependent appetite.
MedLine Citation:
PMID:  15464019     Owner:  NLM     Status:  MEDLINE    
The endocannabinoid system consists of several endogenous lipids, including anandamide and 2-arachidonoyl-glycerol (2-AG), and constitute a retrograde signalling system, which modulates neurotransmitter release and synaptic plasticity. Specific brain-type cannabinoid receptors (CB(1)) are widely distributed in the central nervous system, and are localized presynaptically. Mounting evidence, reviewed here, indicates that cannabinoids can act to increase food consumption, and cannabinoid CB(1) receptor antagonists/inverse agonists reduce food intake and suppress operant responding for food rewards. Hence, endocannabinoids provide the first example of a retrograde signalling system, which is strongly implicated in the control of food intake. Benzodiazepine and opioid palatability-dependent appetite are well-established processes supported by several sources of convergent evidence; they provide pharmacological benchmarks against which to evaluate the endocannabinoids. To date, evidence that endocannabinoids specifically modulate palatability as an affective evaluative process is insufficient and not compelling. Endocannabinoids may have important clinical utility in the treatment of human obesity and forms of eating disorders.
Steven J Cooper
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  European journal of pharmacology     Volume:  500     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  37-49     Citation Subset:  IM    
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK.
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MeSH Terms
Appetite Regulation / drug effects,  physiology*
Benzodiazepines / pharmacology*
Eating / drug effects,  physiology*
Eating Disorders / drug therapy
Endocannabinoids / physiology*
Narcotics / pharmacology*
Obesity / drug therapy
Receptor, Cannabinoid, CB1 / agonists,  antagonists & inhibitors
Signal Transduction
Reg. No./Substance:
0/Endocannabinoids; 0/Narcotics; 0/Receptor, Cannabinoid, CB1; 12794-10-4/Benzodiazepines

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