| Endocannabinoids and food consumption: comparisons with benzodiazepine and opioid palatability-dependent appetite. | |
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MedLine Citation:
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PMID: 15464019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endocannabinoid system consists of several endogenous lipids, including anandamide and 2-arachidonoyl-glycerol (2-AG), and constitute a retrograde signalling system, which modulates neurotransmitter release and synaptic plasticity. Specific brain-type cannabinoid receptors (CB(1)) are widely distributed in the central nervous system, and are localized presynaptically. Mounting evidence, reviewed here, indicates that cannabinoids can act to increase food consumption, and cannabinoid CB(1) receptor antagonists/inverse agonists reduce food intake and suppress operant responding for food rewards. Hence, endocannabinoids provide the first example of a retrograde signalling system, which is strongly implicated in the control of food intake. Benzodiazepine and opioid palatability-dependent appetite are well-established processes supported by several sources of convergent evidence; they provide pharmacological benchmarks against which to evaluate the endocannabinoids. To date, evidence that endocannabinoids specifically modulate palatability as an affective evaluative process is insufficient and not compelling. Endocannabinoids may have important clinical utility in the treatment of human obesity and forms of eating disorders. |
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Authors:
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Steven J Cooper |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: European journal of pharmacology Volume: 500 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2005-06-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 37-49 Citation Subset: IM |
Affiliation:
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Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK. sjcooper@liverpool.ac.uk. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / drug effects, physiology* Benzodiazepines / pharmacology* Eating / drug effects, physiology* Eating Disorders / drug therapy Endocannabinoids / physiology* Humans Narcotics / pharmacology* Obesity / drug therapy Receptor, Cannabinoid, CB1 / agonists, antagonists & inhibitors Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids; 0/Narcotics; 0/Receptor, Cannabinoid, CB1; 12794-10-4/Benzodiazepines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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