| Endocannabinoids as mediators in the heart: a potential target for therapy of remodelling after myocardial infarction? | |
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MedLine Citation:
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PMID: 12711614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocannabinoid production by platelets and macrophages is increased in circulatory shock. This may be protective of the cardiovascular system as blockade of CB(1) cannabinoid receptors exacerbates endothelial dysfunction in haemorrhagic and endotoxin shock and reduces survival. Now evidence suggests that blockade of CB(1) receptors starting 24 h after myocardial infarction in rats has a deleterious effect on cardiac performance, while use of a nonselective cannabinoid receptor agonist prevents hypotension and reduces endothelial dysfunction, although left ventricular end diastolic pressure is elevated. Cannabinoids and endocannabinoid systems may therefore present useful targets for therapy following myocardial infarction. |
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Authors:
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C Robin Hiley; William R Ford |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: British journal of pharmacology Volume: 138 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-24 Completed Date: 2003-12-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 1183-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD. crh1@cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endocannabinoids
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therapeutic use* Heart / drug effects*, physiopathology* Humans Myocardial Infarction / drug therapy* Receptors, Cannabinoid / drug effects* Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids; 0/Receptors, Cannabinoid |
| Comments/Corrections | |
Comment On:
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Br J Pharmacol. 2003 Apr;138(7):1251-8
[PMID:
12711625
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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