| Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. | |
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MedLine Citation:
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PMID: 20837524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In most mammals, placentation is critical for fetal development and pregnancy success. Exposure to marijuana during pregnancy has adverse effects, but whether the placenta is a target of cannabinoid/endocannabinoid signaling is not known. Using mice as a model system, we found that the endocannabinoid system is present in the ectoplacental cone and spongiotrophoblast cells. We also observed that aberrant endocannabinoid signaling confers premature trophoblast stem cell differentiation, and defective trophoblast development and invasion. These defects are reflected in retarded fetal development and compromised pregnancy outcome. Because the endocannabinoid system is conserved in mice and humans, our study suggests that endocannabinoid signaling is critical to placentation and pregnancy success in humans and implicates its potential significance in stem cell biology. |
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Authors:
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Xiaofei Sun; Huirong Xie; Jie Yang; Haibin Wang; Heather B Bradshaw; Sudhansu K Dey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-13 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2010-10-28 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 16887-92 Citation Subset: IM |
Affiliation:
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Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation* Cell Lineage* Cell Proliferation Endocannabinoids / genetics, metabolism* Female Fetal Death / genetics Mice Mice, Knockout Placentation / genetics, physiology* Pregnancy Receptor, Cannabinoid, CB1 / genetics Signal Transduction Trophoblasts / cytology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DA018224/DA/NIDA NIH HHS; DA06668/DA/NIDA NIH HHS; HD12304/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids; 0/Receptor, Cannabinoid, CB1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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