| Endocannabinoid modulation in the olfactory epithelium. | |
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MedLine Citation:
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PMID: 20865377 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Appetite, food intake, and energy balance are closely linked to the endocannabinoid system in the central nervous system. Now, endocannabinoid modulation has been discovered in the peripheral olfactory system of larval Xenopus laevis. The endocannabinoid 2-AG has been shown to influence odorant-detection thresholds according to the hunger state of the animal. Hungry animals have increased 2-AG levels due to enhanced synthesis of 2-AG in sustentacular supporting cells. This renders olfactory receptor neurons, exhibiting CB1 receptors, more sensitive at detecting lower odorant concentrations, which probably helps the animal to locate food. Since taste and vision are also influenced by endocannabinoids, this kind of modulation might boost sensory inputs of food in hungry animals. |
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Authors:
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Esther Breunig; Dirk Czesnik; Fabiana Piscitelli; Vincenzo Di Marzo; Ivan Manzini; Detlev Schild |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Results and problems in cell differentiation Volume: 52 ISSN: 0080-1844 ISO Abbreviation: Results Probl Cell Differ Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173555 Medline TA: Results Probl Cell Differ Country: Germany |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Department of Neurophysiology and Cellular Biophysics, University of Göttingen, 37073 Göttingen, Germany. ebreuni@gwdg.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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