Document Detail

Endocannabinoid modulation in the olfactory epithelium.
MedLine Citation:
PMID:  20865377     Owner:  NLM     Status:  In-Process    
Appetite, food intake, and energy balance are closely linked to the endocannabinoid system in the central nervous system. Now, endocannabinoid modulation has been discovered in the peripheral olfactory system of larval Xenopus laevis. The endocannabinoid 2-AG has been shown to influence odorant-detection thresholds according to the hunger state of the animal. Hungry animals have increased 2-AG levels due to enhanced synthesis of 2-AG in sustentacular supporting cells. This renders olfactory receptor neurons, exhibiting CB1 receptors, more sensitive at detecting lower odorant concentrations, which probably helps the animal to locate food. Since taste and vision are also influenced by endocannabinoids, this kind of modulation might boost sensory inputs of food in hungry animals.
Esther Breunig; Dirk Czesnik; Fabiana Piscitelli; Vincenzo Di Marzo; Ivan Manzini; Detlev Schild
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  52     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Department of Neurophysiology and Cellular Biophysics, University of Göttingen, 37073 Göttingen, Germany.
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