Document Detail

Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope.
MedLine Citation:
PMID:  16278487     Owner:  NLM     Status:  MEDLINE    
Endocannabinoids are a class of fatty acid derivatives defined by their ability to interact with the specific cannabinoid receptors that were originally identified as the targets of Delta9-tetrahydocannabinol (Delta9-THC), the psychoactive component of cannabis. Endocannabinoids have been implicated in a growing number of important physiological and behavioral events. A full understanding of the functions of endocannabinoids will involve knowing which ones are active, and how they are produced, during any given physical event. However, studying these small lipids in the brain presents many technical challenges. New selective pharmacological tools promise to be very useful in unraveling the complexities of endocannabinoid signaling, but parallel developments from the investigation of the cellular neurophysiology of the endocannabinoid systems highlight the difficulties remaining.
Bradley E Alger
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-11-08
Journal Detail:
Title:  Science's STKE : signal transduction knowledge environment     Volume:  2005     ISSN:  1525-8882     ISO Abbreviation:  Sci. STKE     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-09     Completed Date:  2006-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100964423     Medline TA:  Sci STKE     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe51     Citation Subset:  IM    
Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Amidohydrolases / physiology
Arachidonic Acids / physiology
Brain Chemistry*
Endocannabinoids / analysis*,  physiology
Glycerides / physiology
Lipids / physiology
Mice, Knockout
Nitric Oxide / physiology
Receptors, Cannabinoid / drug effects,  physiology
Receptors, G-Protein-Coupled / physiology
Signal Transduction / physiology
Synaptic Transmission / physiology
TRPV Cation Channels / drug effects,  physiology
Type C Phospholipases / physiology
Reg. No./Substance:
0/Arachidonic Acids; 0/Endocannabinoids; 0/Glycerides; 0/Lipids; 0/Receptors, Cannabinoid; 0/Receptors, G-Protein-Coupled; 0/TRPV Cation Channels; 10102-43-9/Nitric Oxide; 53847-30-6/2-arachidonylglycerol; EC 3.1.4.-/Type C Phospholipases; EC 3.5.-/Amidohydrolases; EC 3.5.1.-/fatty-acid amide hydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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