| Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope. | |
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MedLine Citation:
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PMID: 16278487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocannabinoids are a class of fatty acid derivatives defined by their ability to interact with the specific cannabinoid receptors that were originally identified as the targets of Delta9-tetrahydocannabinol (Delta9-THC), the psychoactive component of cannabis. Endocannabinoids have been implicated in a growing number of important physiological and behavioral events. A full understanding of the functions of endocannabinoids will involve knowing which ones are active, and how they are produced, during any given physical event. However, studying these small lipids in the brain presents many technical challenges. New selective pharmacological tools promise to be very useful in unraveling the complexities of endocannabinoid signaling, but parallel developments from the investigation of the cellular neurophysiology of the endocannabinoid systems highlight the difficulties remaining. |
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Authors:
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Bradley E Alger |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-11-08 |
Journal Detail:
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Title: Science's STKE : signal transduction knowledge environment Volume: 2005 ISSN: 1525-8882 ISO Abbreviation: Sci. STKE Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-09 Completed Date: 2006-04-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100964423 Medline TA: Sci STKE Country: United States |
Other Details:
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Languages: eng Pagination: pe51 Citation Subset: IM |
Affiliation:
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Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA. balger@umaryland.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amidohydrolases
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physiology Animals Arachidonic Acids / physiology Brain Chemistry* Endocannabinoids / analysis*, physiology Forecasting Glycerides / physiology Humans Lipids / physiology Mice Mice, Knockout Nitric Oxide / physiology Receptors, Cannabinoid / drug effects, physiology Receptors, G-Protein-Coupled / physiology Signal Transduction / physiology Synaptic Transmission / physiology TRPV Cation Channels / drug effects, physiology Type C Phospholipases / physiology |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Endocannabinoids; 0/Glycerides; 0/Lipids; 0/Receptors, Cannabinoid; 0/Receptors, G-Protein-Coupled; 0/TRPV Cation Channels; 10102-43-9/Nitric Oxide; 53847-30-6/2-arachidonylglycerol; EC 3.1.4.-/Type C Phospholipases; EC 3.5.-/Amidohydrolases; EC 3.5.1.-/fatty-acid amide hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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