| Endocannabinoid-dopamine interactions in striatal synaptic plasticity. | |
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MedLine Citation:
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PMID: 22529814 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum. Signaling through the D2 dopamine receptor is necessary for endocannabinoid-mediated depression of corticostriatal glutamate release. Here we review the known details of this mechanism and discuss newly discovered signaling pathways interacting with this system that ultimately exert dynamic control of cortical input to the striatum and striatal output. This topic is timely with respect to Parkinson's disease given recent data indicating changes in the striatal endocannabinoid system in patients with this disorder. |
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Authors:
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Brian N Mathur; David M Lovinger |
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Publication Detail:
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Type: Journal Article Date: 2012-04-19 |
Journal Detail:
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Title: Frontiers in pharmacology Volume: 3 ISSN: 1663-9812 ISO Abbreviation: Front Pharmacol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101548923 Medline TA: Front Pharmacol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 66 Citation Subset: - |
Affiliation:
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Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health Rockville, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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