| Endocannabinoid control of food intake and energy balance. | |
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MedLine Citation:
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PMID: 15856067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marijuana and its major psychotropic component, Delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. The endocannabinoid system controls food intake via both central and peripheral mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes. |
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Authors:
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Vincenzo Di Marzo; Isabel Matias |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nature neuroscience Volume: 8 ISSN: 1097-6256 ISO Abbreviation: Nat. Neurosci. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-27 Completed Date: 2005-07-08 Revised Date: 2007-10-17 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 585-9 Citation Subset: IM |
Affiliation:
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Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy. vdimarzo@icmib.na.cnr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism,
physiopathology Animals Anti-Obesity Agents / pharmacology, therapeutic use Appetite Regulation / drug effects, physiology* Brain / metabolism*, physiopathology Endocannabinoids / agonists, antagonists & inhibitors, metabolism* Energy Metabolism / drug effects, physiology* Humans Neural Pathways / metabolism, physiopathology Obesity / drug therapy, metabolism, physiopathology Piperidines / pharmacology, therapeutic use Pyrazoles / pharmacology, therapeutic use Receptor, Cannabinoid, CB1 / agonists, antagonists & inhibitors, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Endocannabinoids; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 158681-13-1/rimonabant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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