Document Detail

Endocannabinoid control of food intake and energy balance.
MedLine Citation:
PMID:  15856067     Owner:  NLM     Status:  MEDLINE    
Marijuana and its major psychotropic component, Delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. The endocannabinoid system controls food intake via both central and peripheral mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes.
Vincenzo Di Marzo; Isabel Matias
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature neuroscience     Volume:  8     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-07-08     Revised Date:  2007-10-17    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  IM    
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism,  physiopathology
Anti-Obesity Agents / pharmacology,  therapeutic use
Appetite Regulation / drug effects,  physiology*
Brain / metabolism*,  physiopathology
Endocannabinoids / agonists,  antagonists & inhibitors,  metabolism*
Energy Metabolism / drug effects,  physiology*
Neural Pathways / metabolism,  physiopathology
Obesity / drug therapy,  metabolism,  physiopathology
Piperidines / pharmacology,  therapeutic use
Pyrazoles / pharmacology,  therapeutic use
Receptor, Cannabinoid, CB1 / agonists,  antagonists & inhibitors,  metabolism*
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Endocannabinoids; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 158681-13-1/rimonabant

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