Document Detail

Endemic Japanese encephalitis in the Kathmandu valley, Nepal.
MedLine Citation:
PMID:  18165538     Owner:  NLM     Status:  MEDLINE    
Japanese encephalitis (JE) is endemic in the Terai region of Nepal. There is little information on the occurrence of JE outside the Terai and particularly in the densely populated Kathmandu valley. Acute encephalitis syndrome (AES) cases were detected using a sentinel surveillance system that has been functioning since 2004. JE was confirmed using anti-JE IgM ELISA. All laboratory-confirmed JE cases that occurred in the Kathmandu valley during 2006 were followed up for verification of residence and travel history. JE was confirmed in 40 residents of the Kathmandu valley, including 30 cases that had no history of travel outside the valley during the incubation period. Incidence was 2.1/100,000 and the case fatality was 20% (8/40). Currently, JE prevention is focused on the Terai region in Nepal; given the evidence, this should be reviewed for the possible inclusion of the Kathmandu valley in the national JE prevention and control program.
Jeffrey Partridge; Prakash Ghimire; Tika Sedai; Mahendra Bahadur Bista; Manas Banerjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  77     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-9     Citation Subset:  AIM; IM    
World Health Organization, Immunization Preventable Diseases Unit, Kathmandu, Nepal. <>
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MeSH Terms
Antibodies, Viral / blood,  metabolism
Child, Preschool
Encephalitis Virus, Japanese / immunology,  isolation & purification*
Encephalitis, Japanese / epidemiology*,  immunology
Endemic Diseases*
Enzyme-Linked Immunosorbent Assay / methods
Immunoglobulin M / blood,  metabolism
Middle Aged
Nepal / epidemiology
Population Surveillance
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin M

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