| End-to-end compression anastomosis of the rectum: a pig model. | |
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MedLine Citation:
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PMID: 17334866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Generations of investigators have attempted to achieve compression bowel anastomosis by a sutureless device, providing temporary support to the tissue and facilitating the natural healing process. The biocompatibility of nickel-titanium alloy has made it attractive for use in medical implants and devices, and several studies have described the creation of a side-to-side compression anastomosis in colon surgery with a nickel-titanium clip. We evaluated the feasibility and safety of a newly designed gun for applying a nickel-titanium compression anastomosis ring (CAR) to create an end-to-end colorectal anastomosis in a porcine model. MATERIALS AND METHODS: A segment of the proximal rectum was resected in 25 pigs. The bowel ends were anastomosed transanally by an end-to-end CAR device. The animals' follow-up continued for up to 8 weeks, and included general health status, weight gain, blood tests, and abdominal X-ray. They were then sacrificed. The anastomoses were studied for burst pressure, anastomotic index, and histopathology. RESULTS: One pig died due to iatrogenic bowel injury unrelated to the CAR device. There was no other morbidity/mortality. The other animals recovered and gained weight. Burst pressure studies demonstrated a minimum pressure of 160 mmHg at time point 0 that escalated quickly to >300 mmHg. The mean anastomotic index after 8 weeks was 0.81. Histologic evaluation revealed minimal inflammation and minimal fibrosis at the anastomosis site. CONCLUSION: The principles of compression anastomosis are better executed with the use of memory shape alloys. The promising results of this novel technique should encourage further studies of this technology. |
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Authors:
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Doron Kopelman; Shlomo Lelcuk; Joel Sayfan; Ibrahim Matter; Ehud P Willenz; Luis Zaidenstein; Ossama A Hatoum; Boaz Kimmel; Amir Szold |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of surgery Volume: 31 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 532-7 Citation Subset: IM |
Affiliation:
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Department of Surgery B, HaEmek Medical Center, Afula, Israel. Kopelman_d@clalit.org.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical
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instrumentation* Animals Biocompatible Materials Feasibility Studies Female Nickel Prosthesis Design Prosthesis Implantation Rectum / surgery* Swine Titanium |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 7440-02-0/Nickel; 7440-32-6/Titanium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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