Document Detail

End-tidal pressure of CO2 and exercise performance in healthy subjects.
MedLine Citation:
PMID:  18521623     Owner:  NLM     Status:  MEDLINE    
High arterial CO(2) pressure (P(a)CO(2)) measured in athletes during exercise suggests inadequate hyperventilation. End-tidal CO(2) pressure (P (ET)CO(2)) is used to estimate P(a)CO(2.) However, P(ET)CO(2) also depends on exercise intensity (CO(2) production, .VCO2) and ventilation efficiency (being P(ET)CO(2) function of respiratory rate). We evaluated P(ET)CO(2) as a marker, which combines efficiency of ventilation and performance. A total of 45 well-trained volunteers underwent cardiopulmonary tests and were grouped according to P(ET)CO(2) at respiratory compensation (RC): Group 1 (P(ET)CO(2) 35.1-41.5 mmHg), Group 2 (41.6-45.7) and Group 3 (45.8-62.6). At anaerobic threshold, RC and peak exercise, ventilation (.VE) was similar, but in Group 3, a greater tidal volume (Vt) and lower respiratory rate (RR) were observed. Peak exercise workload and .VO2 were lowest in Group 1 and similar between Group 2 and 3. Group 3 subjects also showed high peak .VCO2 suggesting a greater glycolytic metabolism. In conclusion, a high P(ET)CO(2) during exercise is useful in identifying a specific respiratory pattern characterized by high tidal volume and low respiratory rate. This respiratory pattern may belong to subjects with potential high performance.
Maurizio Bussotti; Damiano Magrì; Emanuele Previtali; Stefania Farina; Anna Torri; Marco Matturri; Piergiuseppe Agostoni
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Publication Detail:
Type:  Journal Article     Date:  2008-06-03
Journal Detail:
Title:  European journal of applied physiology     Volume:  103     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-19     Completed Date:  2008-09-09     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  727-32     Citation Subset:  IM    
Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Università degli Studi di Milano, Via Parea 4, Milan, Italy.
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MeSH Terms
Anaerobic Threshold
Carbon Dioxide / blood,  metabolism*
Hyperventilation / metabolism,  physiopathology
Middle Aged
Muscle, Skeletal / metabolism*
Partial Pressure
Pulmonary Ventilation*
Reference Values
Respiratory Mechanics*
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comment In:
Eur J Appl Physiol. 2009 Apr;105(6):977-8; author reply 979-80   [PMID:  19125278 ]

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