Document Detail

End-stage coxarthrosis and gonarthrosis. Aetiology, clinical patterns and radiological features of idiopathic osteoarthritis.
MedLine Citation:
PMID:  10888705     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine and compare the aetiological background, clinical patterns and radiological features of idiopathic osteoarthritis (OA) of the hip and the knee warranting arthroplasty. METHODS: A total of 402 Caucasians consecutively undergoing total hip replacement (THR) or total knee replacement (TKR) for idiopathic OA at a major centre was surveyed. RESULTS: Previous joint injury was more common in the TKR group (P < 0.0001). However, both groups manifested a mixed occupational background, body mass indices similar to the general population and a predominance of females (F:M = 1.3-1.4:1). The TKR group had a significantly younger age of symptom onset (56 yr) than the THR group (61 yr) but both groups had a tendency to bilateral arthroplasty (33%), nodal involvement (54-59%), a significant excess of right-sided replacements (1.8:1, THR; 2.2:1, TKR) and similar levels of pre-operative pain and disability. Up to 40% of hips manifested acetabular dysplasia and 10% possible previous slipped upper femoral epiphyses. Eighty-five per cent with end-stage coxarthrosis or gonarthrosis had an identical pattern of radiographic disease contralaterally. CONCLUSIONS: Our data suggest the importance of a constitutional tendency to idiopathic, end-stage OA, a disorder traditionally associated with environmental factors leading to 'wear and tear'.
J Chitnavis; J S Sinsheimer; M A Suchard; K Clipsham; A J Carr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  39     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  612-9     Citation Subset:  AIM; IM    
Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK and. University of California, Los Angeles, CA, USA.
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MeSH Terms
Age of Onset
Aged, 80 and over
Analgesics / therapeutic use
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Body Mass Index
Disease Progression
Middle Aged
Osteoarthritis, Hip / etiology,  physiopathology*,  radiography
Osteoarthritis, Knee / etiology,  physiopathology*,  radiography
Pain / drug therapy,  etiology
Sex Factors
Total Quality Management
Reg. No./Substance:

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