| End organ damage in hypertension. | |
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MedLine Citation:
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PMID: 21191547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: End organ damage in hypertension can be detected early, reflects accurately the hypertensive patient's overall cardiovascular risk, and should be prevented and treated with antihypertensive treatment. METHOD: We selectively review the relevant literature since 1995, including the German and European guidelines for the diagnosis and treatment of arterial hypertension. RESULTS: Measurement of the intima-media thickness in the common carotid artery and of the pulse-wave velocity is now recommended for the early diagnosis of hypertensive vasculopathy. Left ventricular hypertrophy, an important component of hypertensive heart disease, can be diagnosed by echocardiography and with the aid of new electrocardiographic indices. Early signs of hypertensive nephropathy, namely albuminuria and a decreased glomerular filtration rate, are prognostically valuable and easy to detect. Cerebrovascular damage, including early microangiopathic changes, is best diagnosed by magnetic resonance imaging. The treatment of end organ damage due to hypertension centers on blood pressure reduction. Blockade of the renin angiotensin-aldosterone system is an essential part of the treatment of early end organ damage. CONCLUSION: Hypertensive end organ damage can now be diagnosed early and reversed with specific and aggressive treatment. |
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Authors:
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Roland E Schmieder |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Review Date: 2010-12-10 |
Journal Detail:
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Title: Deutsches Ärzteblatt international Volume: 107 ISSN: 1866-0452 ISO Abbreviation: Dtsch Arztebl Int Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-30 Completed Date: 2011-04-18 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 101475967 Medline TA: Dtsch Arztebl Int Country: Germany |
Other Details:
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Languages: eng Pagination: 866-73 Citation Subset: IM |
Affiliation:
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Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, 91054 Erlangen, Germany. roland.schmieder@uk-erlangen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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diagnosis*,
epidemiology*,
therapy Cerebrovascular Disorders / diagnosis*, epidemiology*, therapy Comorbidity Early Diagnosis Humans Hypertension / diagnosis*, epidemiology*, therapy Prevalence Risk Assessment Risk Factors |
| Comments/Corrections | |
Comment In:
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Dtsch Arztebl Int. 2011 Mar;108(11):187; author reply 187-8
[PMID:
21475567
]
Dtsch Arztebl Int. 2011 Mar;108(11):187; author reply 187-8 [PMID: 21475569 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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