Document Detail

End organ damage in hypertension.
MedLine Citation:
PMID:  21191547     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: End organ damage in hypertension can be detected early, reflects accurately the hypertensive patient's overall cardiovascular risk, and should be prevented and treated with antihypertensive treatment.
METHOD: We selectively review the relevant literature since 1995, including the German and European guidelines for the diagnosis and treatment of arterial hypertension.
RESULTS: Measurement of the intima-media thickness in the common carotid artery and of the pulse-wave velocity is now recommended for the early diagnosis of hypertensive vasculopathy. Left ventricular hypertrophy, an important component of hypertensive heart disease, can be diagnosed by echocardiography and with the aid of new electrocardiographic indices. Early signs of hypertensive nephropathy, namely albuminuria and a decreased glomerular filtration rate, are prognostically valuable and easy to detect. Cerebrovascular damage, including early microangiopathic changes, is best diagnosed by magnetic resonance imaging. The treatment of end organ damage due to hypertension centers on blood pressure reduction. Blockade of the renin angiotensin-aldosterone system is an essential part of the treatment of early end organ damage.
CONCLUSION: Hypertensive end organ damage can now be diagnosed early and reversed with specific and aggressive treatment.
Roland E Schmieder
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2010-12-10
Journal Detail:
Title:  Deutsches Ärzteblatt international     Volume:  107     ISSN:  1866-0452     ISO Abbreviation:  Dtsch Arztebl Int     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-04-18     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101475967     Medline TA:  Dtsch Arztebl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  866-73     Citation Subset:  IM    
Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
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MeSH Terms
Cardiovascular Diseases / diagnosis*,  epidemiology*,  therapy
Cerebrovascular Disorders / diagnosis*,  epidemiology*,  therapy
Early Diagnosis
Hypertension / diagnosis*,  epidemiology*,  therapy
Risk Assessment
Risk Factors
Comment In:
Dtsch Arztebl Int. 2011 Mar;108(11):187; author reply 187-8   [PMID:  21475567 ]
Dtsch Arztebl Int. 2011 Mar;108(11):187; author reply 187-8   [PMID:  21475569 ]

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