Document Detail

End-faced waveguide mediated optical propulsion of microspheres and single cells in a microfluidic device.
MedLine Citation:
PMID:  23411834     Owner:  NLM     Status:  Publisher    
Single cell transport in microfluidic devices is a topic of interest as their utility is becoming appreciated by cell and molecular biologist. Cell transport should minimize mechanical stress due to friction or pressure gradients. Optical forces have the advantage of applying their forces across the cell volume and not only at the cell membrane and are thus preferable. Optical pushing by scattering force is a suitable candidate so highly dependent on the photon irradiance field inside the propagation capillary which in turn is determined by the waveguide properties delivering the radiation pressure. Here we present a numerical approach to predict the optical scattering force, speed and trajectory of cells as a function of waveguide and propagation capillary geometry. Experimental verification of the simulation approach is demonstrated using polystyrene microspheres and leukemia cells. Effects of optical fibre to waveguide alignment, capillary wall angle and temperature on the dynamic viscosity on speed and position of the microspheres and cells inside the propagation capillary are demonstrated.
Lothar Lilge; Duoaud Shah; Luc Charron
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Lab on a chip     Volume:  -     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medical Biophysics, University of Toronto, Toronto, Canada and Division of Biophotonics and Bioimaging, Ontario Cancer Institute, University Health Network, Toronto, Canada.
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