| End-expiratory lung volume during arm and leg exercise in normal subjects and patients with cystic fibrosis. | |
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MedLine Citation:
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PMID: 9817692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are no reports concerning the regulation of end-expiratory lung volume (EELV) and flow-volume relationships during upper limb exercise in health and disease. We studied EELV during such exercise in 22 adults with cystic fibrosis (CF) and nine age-matched healthy control subjects. Subjects with CF were grouped according to the severity of their lung disease, as follows: mild = FEV1 > 80% predicted; moderate = FEV1 40 to 80% predicted, and severe = FEV1 < 40% predicted. EELV was calculated from measurements of inspiratory capacity (IC) made at each workload during an incremental arm and leg ergometer test to peak work capacity. In the control group, the decrease in EELV was significantly smaller for arm than for leg exercise at peak work (-0.13 L versus -0.53 L, p < 0.001) and for arm than for leg exercise at an equivalent submaximal ventilation (-0.13 L versus -0.46 L, p < 0.01). In the groups with moderate and severe CF, arm exercise resulted in an increase in EELV from resting levels (dynamic hyperinflation) that was not significantly different from the increase observed for leg exercise. For CF subjects there was a significant inverse relationship between FEV1 and changes in EELV from rest to peak arm exercise (r = -0.46, p < 0.05). In normal subjects, there was a difference in the EELV response for arm versus leg exercise. In CF subjects with airflow limitation, dynamic hyperinflation occurred with both forms of exercise. |
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Authors:
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J A Alison; J A Regnis; P M Donnelly; R D Adams; C E Sullivan; P T Bye |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 158 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-18 Completed Date: 1998-12-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1450-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia. j.alison@cchs.usyd.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arm / physiology* Case-Control Studies Cystic Fibrosis / physiopathology* Exercise Test Female Forced Expiratory Volume / physiology Humans Inspiratory Capacity / physiology Leg / physiology* Lung / physiopathology Lung Compliance / physiology Male Physical Exertion / physiology* Pulmonary Ventilation / physiology* Residual Volume / physiology Respiration Severity of Illness Index Total Lung Capacity / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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