Document Detail


End-expiratory lung volume during arm and leg exercise in normal subjects and patients with cystic fibrosis.
MedLine Citation:
PMID:  9817692     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are no reports concerning the regulation of end-expiratory lung volume (EELV) and flow-volume relationships during upper limb exercise in health and disease. We studied EELV during such exercise in 22 adults with cystic fibrosis (CF) and nine age-matched healthy control subjects. Subjects with CF were grouped according to the severity of their lung disease, as follows: mild = FEV1 > 80% predicted; moderate = FEV1 40 to 80% predicted, and severe = FEV1 < 40% predicted. EELV was calculated from measurements of inspiratory capacity (IC) made at each workload during an incremental arm and leg ergometer test to peak work capacity. In the control group, the decrease in EELV was significantly smaller for arm than for leg exercise at peak work (-0.13 L versus -0.53 L, p < 0.001) and for arm than for leg exercise at an equivalent submaximal ventilation (-0.13 L versus -0.46 L, p < 0.01). In the groups with moderate and severe CF, arm exercise resulted in an increase in EELV from resting levels (dynamic hyperinflation) that was not significantly different from the increase observed for leg exercise. For CF subjects there was a significant inverse relationship between FEV1 and changes in EELV from rest to peak arm exercise (r = -0.46, p < 0.05). In normal subjects, there was a difference in the EELV response for arm versus leg exercise. In CF subjects with airflow limitation, dynamic hyperinflation occurred with both forms of exercise.
Authors:
J A Alison; J A Regnis; P M Donnelly; R D Adams; C E Sullivan; P T Bye
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  158     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1450-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia. j.alison@cchs.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arm / physiology*
Case-Control Studies
Cystic Fibrosis / physiopathology*
Exercise Test
Female
Forced Expiratory Volume / physiology
Humans
Inspiratory Capacity / physiology
Leg / physiology*
Lung / physiopathology
Lung Compliance / physiology
Male
Physical Exertion / physiology*
Pulmonary Ventilation / physiology*
Residual Volume / physiology
Respiration
Severity of Illness Index
Total Lung Capacity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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