Document Detail

End-expiratory lung impedance change enables bedside monitoring of end-expiratory lung volume change.
MedLine Citation:
PMID:  12528020     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside. DESIGN: Clinical trial on patients requiring mechanical ventilation. SETTINGS: Intensive care units of a university hospital. PATIENTS: Ten mechanically ventilated patients were included in the study. INTERVENTION: Patients were ventilated in volume-controlled mode with constant flow and respiratory rate. In order to induce changes in the end-expiratory lung volume (EELV), PEEP levels were increased from 0 mbar to 5 mbar, 10 mbar, and 15 mbar. At each PEEP level EELV was measured by an open-circuit nitrogen washout manoeuvre and ELIC was measured simultaneously using Electrical Impedance Tomography (EIT) with sixteen electrodes placed on the circumference of the thorax and connected with an EIT device. Cross-sectional electro-tomographic measurements of the thorax were performed at each PEEP level, and a modified Sheffield back-projection was used to reconstruct images of the lung impedance. ELIC was calculated as the average of the end-expiratory lung impedance change. RESULTS. Increasing PEEP stepwise from 0 mbar to 15 mbar resulted in an linear increase of EELV and ELIC according to the equation: y =0.98 x -0.68, r(2)=0.95. CONCLUSION: EIT is a simple bedside technique which enables monitor lung volume changes during ventilatory manoeuvres such as PEEP changes.
J Hinz; G Hahn; P Neumann; M Sydow; P Mohrenweiser; G Hellige; H Burchardi
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-11-20
Journal Detail:
Title:  Intensive care medicine     Volume:  29     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electric Impedance*
Least-Squares Analysis
Lung Volume Measurements / methods*
Middle Aged
Nitrogen / analysis
Point-of-Care Systems*
Positive-Pressure Respiration*
Respiratory Mechanics
Statistics, Nonparametric
Tomography / methods*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intra-abdominal pressure monitoring in liver transplant recipients: a prospective study.
Next Document:  Thyroid hormone response to moderate hypothermia in severe brain injury.