Document Detail

Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature.
MedLine Citation:
PMID:  10800067     Owner:  NLM     Status:  MEDLINE    
Haemorrhagic cystitis (HC) after allogeneic haematopoietic stem cell transplantation (HSCT) or high-dose cyclophosphamide (CP) chemotherapy is a severe side-effect and can cause significant morbidity and mortality. In this report, we describe the clinical courses of 10 patients with HC and review the literature. The patients were treated with oral conjugated estrogen in an attempt to improve severe haemorrhagic cystitis. In seven patients positive effects were seen, haematuria resolved in all, but residual symptoms of dysuria remained for longer periods. In one patient application of estrogen was interrupted because of hepatotoxicity. Two patients failed all treatment modalities including oral estrogen because of terminal illness. We conclude that in the management of HC the administration of oral conjugated estrogen should be considered.
R Ordemann; R Naumann; G Geissler; M Bornhauser; U Schuler; G Ehninger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  25     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-13     Completed Date:  2000-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  981-5     Citation Subset:  IM    
Department of Medicine I, Technical University of Dresden, University Hospital 'Carl Gustav Carus', Dresden, Germany.
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MeSH Terms
Administration, Oral
Cystitis / drug therapy*,  etiology*
Estrogens / administration & dosage*
Hematopoietic Stem Cell Transplantation / adverse effects*
Middle Aged
Transplantation, Homologous
Reg. No./Substance:

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