Document Detail

Encouraging initial response of restless legs syndrome to pramipexole.
MedLine Citation:
PMID:  9781569     Owner:  NLM     Status:  MEDLINE    
Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.
P M Becker; W Ondo; D Sharon
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  51     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-10-30     Completed Date:  1998-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1221-3     Citation Subset:  AIM; IM    
Sleep Medicine Associates of Texas, University of Texas Southwestern Medical Center at Dallas, USA.
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MeSH Terms
Aged, 80 and over
Dopamine Agonists / administration & dosage*
Middle Aged
Restless Legs Syndrome / drug therapy*
Thiazoles / administration & dosage*
Reg. No./Substance:
0/Benzothiazoles; 0/Dopamine Agonists; 0/Thiazoles; 104632-26-0/pramipexol
Comment In:
Neurology. 1999 Jul 22;53(2):439-40   [PMID:  10430455 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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