Document Detail


Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias.
MedLine Citation:
PMID:  16601345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia. METHODS: Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients. RESULTS: Six of the 8 fetuses survived to discharge from hospital. CONCLUSION: Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.
Authors:
Thomas Kohl; Ulrich Gembruch; Barbara Filsinger; Rudolf Hering; Jorgen Bruhn; Kristina Tchatcheva; Sebastian Aryee; Axel Franz; Axel Heep; Andreas Muller; Peter Bartmann; Stefan Loff; Stuart Hosie; Wolfgang Neff; Thomas Schaible;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  21     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
German Center for Fetal Surgery and Minimally Invasive Therapy, University Hospital of Bonn, Germany. thomas.kohl@ukb.uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Balloon Occlusion*
Female
Fetal Diseases / surgery*
Fetoscopy*
Gestational Age
Hernia, Diaphragmatic / congenital*,  surgery*
Humans
Pregnancy
Time Factors
Trachea*
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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