Document Detail


Encoding a superantigen by Staphylococcus aureus does not affect clinical characteristics of infected atopic dermatitis lesions.
MedLine Citation:
PMID:  20698850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bacterial infection with Staphylococcus aureus is a known trigger for the worsening of atopic dermatitis (AD). Staphylococcal superantigens have been theorized to make a potential contribution to this worsening of AD seen with infection.
OBJECTIVES: We sought to assess whether encoding a superantigen by S. aureus affects the inflammatory characteristics of impetiginized AD skin lesions.
METHODS: Fifty-two children with clinically impetiginized lesions of AD which were positive for S. aureus were enrolled in this study. A lesion was graded clinically using the Eczema Area and Severity Index (EASI), and then wash fluid was obtained from the lesion for quantitative bacterial culture, and measurement of bacterial products lipoteichoic acid and staphylococcal protein A and cytokines. The staphylococcal isolate was tested for antibiotic susceptibilities and the presence of a superantigen.
RESULTS: Fifty-four per cent (28 of 52) of the staphylococcal isolates encoded a superantigen. The presence of a superantigen had no significant effect on EASI score, amounts of bacterial products or inflammatory cytokines in the AD lesion.
CONCLUSIONS: These studies suggest that the expression of a superantigen by S. aureus alone does not play an important role in the increased skin inflammation associated with staphylococcal infection in childhood AD.
Authors:
A Kozman; Y Yao; P Bina; C Saha; W Yao; M H Kaplan; J B Travers
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The British journal of dermatology     Volume:  163     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-04-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1308-11     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / immunology
Bacterial Toxins / immunology
Child
Child, Preschool
Cytokines / analysis
Dermatitis, Atopic / immunology*,  microbiology,  pathology
Eczema / complications,  diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Male
Severity of Illness Index
Staphylococcal Skin Infections / immunology*,  microbiology
Staphylococcus aureus / immunology*
Superantigens / immunology*
Grant Support
ID/Acronym/Agency:
HL62996/HL/NHLBI NIH HHS; R01 HL062996-12/HL/NHLBI NIH HHS; U19 AI070448/AI/NIAID NIH HHS; U19 AI070448/AI/NIAID NIH HHS; U19 AI070448-05S16980/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Cytokines; 0/Superantigens
Comments/Corrections
Comment In:
Br J Dermatol. 2010 Dec;163(6):1147   [PMID:  21137112 ]

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