Document Detail


Encoding of different aspects of afferent activities by two types of cells in the corpus glomerulosum of a teleost brain.
MedLine Citation:
PMID:  11247986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The corpus glomerulosum (CG) is an expansive nucleus in acanthopterigian teleosts that has been suggested to be involved in vision-related information processing and the control of the hypothalamic function. The CG has only two types of constituent cells, the large cell and the small cell, and well-defined afferent/efferent fiber connections. One of the three types of teleostean CG, type III has additional outstanding morphological characters: clearly laminated organization and giant (>50 microm in diameter) tips of postsynaptic dendrites. Although such histological architecture is potentially advantageous for the study of information processing in a brain nucleus based on the physiological properties of identified cells and synapses, previous studies on the CG have been limited to anatomy. In this study, we developed a slice preparation of the type III CG in a teleost, Stephanoplepis cirrhifer, and studied the morphology and physiology of individual cells and synaptic transmission by means of dendritic intracellular and somatic whole cell recordings. The characteristic morphology of the two types of cells was revealed by intracellular staining. While both of them received similar glutamatergic and GABAergic projections from the nucleus corticalis mediated by AMPA, N-methyl-D-aspartate, and GABA(A) receptors, they showed quite distinctive firing properties and postsynaptic responses with current injection and synaptic inputs: the large cell fired a single spike, and the small cell fired a spike train whose frequency was dependent on the stimulus intensity. Furthermore, the large cell showed low-pass temporal filtering properties with paired stimuli. These results suggest that the large cell and the small cell may encode different aspects of the corticalis activities.
Authors:
H Tsutsui; N Yamamoto; H Ito; Y Oka
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  85     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-77     Citation Subset:  IM    
Affiliation:
Misaki Marine Biological Station, Graduate School of Science, The University of Tokyo, Kanagawa 238-0225, Japan.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology
Animals
Brain / cytology*,  physiology*
Cholinergic Agonists / pharmacology
Cholinergic Antagonists / pharmacology
Electric Stimulation
Excitatory Amino Acid Antagonists / pharmacology
Excitatory Postsynaptic Potentials / drug effects,  physiology
Female
Fishes
GABA Antagonists / pharmacology
Glutamic Acid / metabolism
Male
Membrane Potentials / drug effects,  physiology
Neurons, Afferent / classification*,  cytology,  drug effects,  physiology*
Patch-Clamp Techniques
Reaction Time / drug effects,  physiology
Receptors, AMPA / metabolism
Receptors, GABA-A / metabolism
Receptors, N-Methyl-D-Aspartate / metabolism
Synaptic Transmission / drug effects,  physiology
Tetrodotoxin / pharmacology
gamma-Aminobutyric Acid / metabolism
Chemical
Reg. No./Substance:
0/Cholinergic Agonists; 0/Cholinergic Antagonists; 0/Excitatory Amino Acid Antagonists; 0/GABA Antagonists; 0/Receptors, AMPA; 0/Receptors, GABA-A; 0/Receptors, N-Methyl-D-Aspartate; 4368-28-9/Tetrodotoxin; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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