Document Detail

Encephalopathy with idiopathic hyperammonaemia and Alzheimer type II astrocytes in equidae.
MedLine Citation:
PMID:  10596928     Owner:  NLM     Status:  MEDLINE    
In 3 mature female horses of varying breeds, episodes of colic and depression for 14 days preceded an encephalopathic disorder with maniacal behaviour, anxiety, profuse sweating and, in one case, terminal opisthotonus. Blood ammonia levels were elevated approximately 10-fold. At necropsy, there were gastrointestinal serosal and mesenteric haemorrhages. Histologically, all 3 cases revealed diffuse Alzheimer type II astrocytes in the cerebral grey matter. Alzheimer type II astrocytes were glial fibrillary acidic protein (GFAP) negative or only weakly positive, weakly S-100 positive, and vimentin negative. In the absence of primary hepatic and/or renal lesions, an increase in intestinal ammonia absorption due to ileus or increased ammonia production by colonic bacteria is hypothesised.
K M Hasel; B A Summers; A De Lahunta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  31     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-24     Completed Date:  2000-02-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  IM    
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14850, USA.
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MeSH Terms
Alzheimer Disease / pathology,  veterinary*
Ammonia / blood*
Astrocytes / pathology*
Brain Diseases, Metabolic / pathology,  veterinary*
Fatal Outcome
Horse Diseases / pathology*
Kidney / pathology
Liver / pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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