| Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. | |
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MedLine Citation:
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PMID: 19953118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A 23 year-old female presented to a neurology department with a 3 year history of recurrent episodes involving hearing loss, encephalopathy, focal neurological deficits, and visual field deficits. In the 3 years before presentation, the patient had been treated with methylprednisolone for suspected acute demyelinating encephalomyelitis and peripheral otogenic dysfunction from which she made a complete recovery, and for a visual defect in both eyes caused by bilateral branch retinal arterial occlusion, from which she partially improved and commenced long-term treatment with acetylsalicylic acid. INVESTIGATIONS: Detailed history, clinical examination, extensive laboratory work-up, cerebrospinal fluid analysis, cerebral and spinal MRI, periventricular single-voxel (1)H magnetic resonance spectroscopy, retinal fluorescence angiography, optical coherence tomography, audiometry, neurophysiological work-up (EEG, evoked potentials). DIAGNOSIS: Susac syndrome, characterized by a combination of encephalopathy, branch retinal artery occlusions, and hearing loss. MANAGEMENT: Long-term immunosuppressive treatment with azathioprine (150 mg/day) and prednisolone (10 mg/day), and inhibition of thrombocyte function with acetylsalicylic acid (100 mg/day). |
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Authors:
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Jan D?rr; Helena Radbruch; Markus Bock; Jens Wuerfel; Anne Br?ggemann; Klaus P Wandinger; Daniel Zeise; Caspar F Pfueller; Frauke Zipp; Friedemann Paul |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature reviews. Neurology Volume: 5 ISSN: 1759-4766 ISO Abbreviation: Nat Rev Neurol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500072 Medline TA: Nat Rev Neurol Country: England |
Other Details:
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Languages: eng Pagination: 683-8 Citation Subset: IM |
Affiliation:
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NeuroCure Clinical Research Center Charit?-Universit?tsmedizin Berlin, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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therapeutic use Auditory Perceptual Disorders / etiology* Brain / pathology* Cerebral Angiography / methods Diagnosis, Differential Disease Progression Female Fibrinolytic Agents / therapeutic use Hearing Loss / etiology* Humans Magnetic Resonance Imaging / methods Susac Syndrome / complications*, diagnosis, drug therapy Vision Disorders / etiology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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