Document Detail


Enantioselective synthesis of aspergillide B.
MedLine Citation:
PMID:  19661704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.
Authors:
Tomohiro Nagasawa; Shigefumi Kuwahara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  73     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1893-4     Citation Subset:  IM    
Affiliation:
Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cytotoxins / chemical synthesis,  chemistry
Macrolides / chemical synthesis*,  chemistry*
Stereoisomerism
Substrate Specificity
Chemical
Reg. No./Substance:
0/Cytotoxins; 0/Macrolides; 0/aspergillide B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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