| Enantioselective Synthesis of β-Pyrazole-Substituted Alcohols through an Asymmetric Ring-Opening Reaction of meso-Epoxides. | |
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MedLine Citation:
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PMID: 22362613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An efficient and practical synthesis of optically pure β-pyrazole-substituted alcohols was achieved from an asymmetric ring-opening reaction of meso-epoxides with pyrazole derivatives as the nucleophile. In the presence of 1 mol % of N,N'-dioxide-Sc(OTf)(3) complex, excellent enantioselectivity and yields were obtained from meso-epoxides. The process could also be used for the mixture of cis- and trans-stilbene oxides. A proposed transition-state model is provided. |
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Authors:
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Xiaolei Hu; Bo Gao; Yangyang Chu; Wei Li; Xiaohua Liu; Lili Lin; Xiaoming Feng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-23 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064(China), Fax: (+86) 28-8541-8249. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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