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Enantioselective Organocatalytic Synthesis of Quaternary α-Amino Acids Bearing a CF(3) Moiety.
MedLine Citation:
PMID:  21348534     Owner:  NLM     Status:  In-Data-Review    
A highly enantioselective Friedel-Crafts reaction catalyzed by a chiral phosphoric acid was developed. N-Boc-protected ethyl trifluoropyruvate imine was activated by 6 mol % of catalyst and reacted with a wide variety of indole derivatives to afford quaternary α-amino acids in excellent yields (up to 99%) and high enantioselectivities (up to 98:2 er).
Ralph Husmann; Erli Sugiono; Stefanie Mersmann; Gerhard Raabe; Magnus Rueping; Carsten Bolm
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Publication Detail:
Type:  Journal Article     Date:  2011-01-24
Journal Detail:
Title:  Organic letters     Volume:  13     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1044-7     Citation Subset:  IM    
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
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