Document Detail

An Enantioselective Approach towards 3,4-Dihydroisocoumarin through the Bromocyclization of Styrene-type Carboxylic Acids.
MedLine Citation:
PMID:  22175914     Owner:  NLM     Status:  Publisher    
A facile and enantioselective approach towards 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ees. 3-bromo-3,4-dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the Br group can readily be modified to achieve biologically important 4-O-type and 4-N-type 3,4-dihydroisocoumarin systems. In addition, studies indicated that by refining some parameters, the synthetically useful 5-exo phthalide products could be achieved with good yields and ees.
Jie Chen; Ling Zhou; Chong Kiat Tan; Ying-Yeung Yeung
Related Documents :
6831994 - Evaluation of an oral ursodeoxycholic acid load in the assessment of bile acid malabsor...
2353164 - Decreased concentrations of deoxycholic acid in serum of uraemic patients with diarrhoea.
7582394 - Effect of tauroursodeoxycholic acid on biliary lipid composition. a dose-response study.
7745974 - Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallb...
6251514 - Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of differe...
22827174 - The medicinal chemistry of (-)-shikimic acid.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-16
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of exercise in hypoxic and normoxic conditions on endothelin-1 and arterial compliance.
Next Document:  Origin of dark-channel X-ray fluorescence from transition-metal ions in water.