| An Enantioselective Approach towards 3,4-Dihydroisocoumarin through the Bromocyclization of Styrene-type Carboxylic Acids. | |
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MedLine Citation:
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PMID: 22175914 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A facile and enantioselective approach towards 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ees. 3-bromo-3,4-dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the Br group can readily be modified to achieve biologically important 4-O-type and 4-N-type 3,4-dihydroisocoumarin systems. In addition, studies indicated that by refining some parameters, the synthetically useful 5-exo phthalide products could be achieved with good yields and ees. |
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Authors:
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Jie Chen; Ling Zhou; Chong Kiat Tan; Ying-Yeung Yeung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: - ISSN: 1520-6904 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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