| Enantiomeric separations using polymeric L-glutamate surfactant derivatives: effect of increasing steric factors. | |
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MedLine Citation:
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PMID: 12658698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examines the role of steric hindrance near the stereogenic centers of four glutamic acid based polymeric surfactants. The single amino acid surfactants of glutamic acid, glutamic acid methyl ester, glutamic ethyl ester, and glutamic acid tert-butyl ester were investigated. The micellar electrokinetic chromatography (MEKC) separation of three binaphthyl derivatives and three benzodiazepines were used to study these steric factors. In addition, the hydrophobicity of these polymers as a function of pH was investigated by use of fluorescence measurements. |
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Authors:
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Stefan J Thibodeaux; Eugene Billiot; Eric Torres; Bertha C Valle; Isiah M Warner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Electrophoresis Volume: 24 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-26 Completed Date: 2003-11-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 1077-82 Citation Subset: IM |
Affiliation:
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Discovery Chemistry Research and Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzodiazepines
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chemistry,
isolation & purification* Biopolymers / chemistry* Electrophoresis, Capillary / methods* Glutamic Acid / analogs & derivatives*, chemistry* Hydrophobicity Molecular Conformation Naphthalenes / chemistry, isolation & purification* Stereoisomerism Surface-Active Agents / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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GM39844/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biopolymers; 0/Naphthalenes; 0/Surface-Active Agents; 12794-10-4/Benzodiazepines; 56-86-0/Glutamic Acid; 91-20-3/naphthalene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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