Document Detail


Enantiomeric separations using polymeric L-glutamate surfactant derivatives: effect of increasing steric factors.
MedLine Citation:
PMID:  12658698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examines the role of steric hindrance near the stereogenic centers of four glutamic acid based polymeric surfactants. The single amino acid surfactants of glutamic acid, glutamic acid methyl ester, glutamic ethyl ester, and glutamic acid tert-butyl ester were investigated. The micellar electrokinetic chromatography (MEKC) separation of three binaphthyl derivatives and three benzodiazepines were used to study these steric factors. In addition, the hydrophobicity of these polymers as a function of pH was investigated by use of fluorescence measurements.
Authors:
Stefan J Thibodeaux; Eugene Billiot; Eric Torres; Bertha C Valle; Isiah M Warner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Electrophoresis     Volume:  24     ISSN:  0173-0835     ISO Abbreviation:  Electrophoresis     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1077-82     Citation Subset:  IM    
Affiliation:
Discovery Chemistry Research and Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
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MeSH Terms
Descriptor/Qualifier:
Benzodiazepines / chemistry,  isolation & purification*
Biopolymers / chemistry*
Electrophoresis, Capillary / methods*
Glutamic Acid / analogs & derivatives*,  chemistry*
Hydrophobicity
Molecular Conformation
Naphthalenes / chemistry,  isolation & purification*
Stereoisomerism
Surface-Active Agents / chemistry*
Grant Support
ID/Acronym/Agency:
GM39844/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Naphthalenes; 0/Surface-Active Agents; 12794-10-4/Benzodiazepines; 56-86-0/Glutamic Acid; 91-20-3/naphthalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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