| Enantiomeric excess determination by fourier transform near-infrared vibrational circular dichroism spectroscopy: simulation of real-time process monitoring. | |
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MedLine Citation:
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PMID: 16197634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first use of near-infrared (NIR) Fourier transform vibrational circular dichroism (FT-VCD) to follow changes in the enantiomeric excess (EE) of chiral sample molecules in time using a flow-cell sampling apparatus is reported. Simultaneous changes in the fractional composition and the EE of a mixture of two different chiral molecules were monitored as a function of time. This simulates the progress of the chemical reaction from a chiral reactant to a chiral product where the mole fractions and EE values of both species may change with time. For the molecules studied, alpha-pinene, camphor, and borneol, the accuracy of following EE changes for one species alone is approximately 2%, while for simultaneously following EE changes in two species it is approximately 3% for 30 min sampling periods at 16 cm(-1) spectral resolution. These findings demonstrate the potential for VCD to be used in the NIR region for real-time monitoring of the composition and %EE of chemical reactions involving the synthesis of chiral molecules. |
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Authors:
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Changning Guo; Rekha D Shah; Rina K Dukor; Xiaolin Cao; Teresa B Freedman; Laurence A Nafie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Applied spectroscopy Volume: 59 ISSN: 0003-7028 ISO Abbreviation: Appl Spectrosc Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-03 Completed Date: 2005-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372406 Medline TA: Appl Spectrosc Country: United States |
Other Details:
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Languages: eng Pagination: 1114-24 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bornanes
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chemistry Camphor / chemistry Circular Dichroism / methods* Monoterpenes / chemistry Spectroscopy, Fourier Transform Infrared / methods* Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Bornanes; 0/Monoterpenes; 10385-78-1/isoborneol; 76-22-2/Camphor; 80-56-8/alpha-pinene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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