Document Detail


Enantiomeric excess determination by fourier transform near-infrared vibrational circular dichroism spectroscopy: simulation of real-time process monitoring.
MedLine Citation:
PMID:  16197634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first use of near-infrared (NIR) Fourier transform vibrational circular dichroism (FT-VCD) to follow changes in the enantiomeric excess (EE) of chiral sample molecules in time using a flow-cell sampling apparatus is reported. Simultaneous changes in the fractional composition and the EE of a mixture of two different chiral molecules were monitored as a function of time. This simulates the progress of the chemical reaction from a chiral reactant to a chiral product where the mole fractions and EE values of both species may change with time. For the molecules studied, alpha-pinene, camphor, and borneol, the accuracy of following EE changes for one species alone is approximately 2%, while for simultaneously following EE changes in two species it is approximately 3% for 30 min sampling periods at 16 cm(-1) spectral resolution. These findings demonstrate the potential for VCD to be used in the NIR region for real-time monitoring of the composition and %EE of chemical reactions involving the synthesis of chiral molecules.
Authors:
Changning Guo; Rekha D Shah; Rina K Dukor; Xiaolin Cao; Teresa B Freedman; Laurence A Nafie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied spectroscopy     Volume:  59     ISSN:  0003-7028     ISO Abbreviation:  Appl Spectrosc     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372406     Medline TA:  Appl Spectrosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1114-24     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA.
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MeSH Terms
Descriptor/Qualifier:
Bornanes / chemistry
Camphor / chemistry
Circular Dichroism / methods*
Monoterpenes / chemistry
Spectroscopy, Fourier Transform Infrared / methods*
Stereoisomerism
Chemical
Reg. No./Substance:
0/Bornanes; 0/Monoterpenes; 10385-78-1/isoborneol; 76-22-2/Camphor; 80-56-8/alpha-pinene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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