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Enantiodivergent, catalytic asymmetric synthesis of gamma-amino vinyl sulfones.
MedLine Citation:
PMID:  12816460     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A set of diversely substituted N-Boc-gamma-amino vinyl sulfones has been prepared by a four-step procedure from readily available, highly enantiopure anti-N-Boc-3-amino-1,2-alkanediols. This new route, which does not depend on the accessibility of alpha-amino acids as starting materials, is noteworthy for its efficiency, for its generality, and for the fact that both enantiomers of a given gamma-amino vinyl sulfone can be obtained with equal ease.
Authors:
Anna Picó; Albert Moyano; Miquel A Pericàs
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  68     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-20     Completed Date:  2004-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5075-83     Citation Subset:  -    
Affiliation:
Unitat de Recerca en Síntesi Asimètrica, Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028-Barcelona, Spain.
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