Document Detail


Enamel matrix derivative in the treatment of human intrabony osseous defects.
MedLine Citation:
PMID:  11156038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is limited information available from clinical trials regarding the performance of enamel matrix derivative (EMD) in the treatment of periodontal intrabony defects. This randomized, double-blind, placebo-controlled, split-mouth study was designed to compare the clinical and radiographical effects of EMD treatment to that of placebo-controlled treatment for intrabony defects. METHODS: Sixteen patients were included, each of whom had 1 or 2 pairs of intrabony defects located contralaterally in the same arch. Thirty-six intrabony defects were randomly assigned treatment with flap surgery plus EMD or flap surgery plus placebo. At baseline and at the 12-month follow-up evaluation visit, clinical and radiographic measurements were determined. Data were statistically analyzed using the Wilcoxon-signed rank test (alpha = 0.05). RESULTS: At the 12-month visit, bleeding on probing for the EMD group was 0.11 +/- 0.32 compared to the placebo group, 0.61 +/- 0.50 (P <0.05). Probing depth reduction was greater in the EMD group (3.00 +/- 0.97 mm) compared to the placebo group (2.22 +/- 0.81 mm) (P <0.05). Mean values for clinical attachment gain in the EMD and the placebo groups were 1.72 +/- 1.07 mm and 0.83 +/- 0.86 mm, respectively (P <0.05). Vertical relative attachment gain was 38.5 +/- 22.6% in the EMD group and 21.4 +/- 25.2% in the placebo group (P<0.05). Radiographic bone density gain was greater in the EMD (20.2 +/- 16.6%) compared to the placebo group (-3.94 +/- 23.3%) (P<0.01). CONCLUSIONS: Treatment with flap surgery and EMD, compared to flap surgery with placebo, produced a significantly more favorable clinical improvement in intrabony periodontal defects.
Authors:
K Okuda; M Momose; A Miyazaki; M Murata; S Yokoyama; Y Yonezawa; L F Wolff; H Yoshie
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of periodontology     Volume:  71     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1821-8     Citation Subset:  D; IM    
Affiliation:
Department of Periodontology, Faculty of Dentistry, Niigata University, Japan. okuda@dent.niigata-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Alveolar Bone Loss / radiography,  surgery*
Alveolar Process / radiography
Bone Density
Bone Substitutes / therapeutic use*
Dental Enamel Proteins / therapeutic use*
Dental Plaque Index
Double-Blind Method
Female
Follow-Up Studies
Gingival Hemorrhage / surgery
Guided Tissue Regeneration, Periodontal / methods
Humans
Male
Middle Aged
Periodontal Attachment Loss / surgery
Periodontal Index
Periodontal Pocket / surgery
Periodontitis / radiography,  surgery
Placebos
Statistics, Nonparametric
Surgical Flaps
Chemical
Reg. No./Substance:
0/Bone Substitutes; 0/Dental Enamel Proteins; 0/Placebos; 0/enamel matrix proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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