| Enalapril. An update of its pharmacological properties and therapeutic use in congestive heart failure. | |
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MedLine Citation:
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PMID: 2539290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enalapril provides significant haemodynamic, symptomatic and clinical improvement when added to maintenance therapy with digitalis and diuretics in patients with congestive heart failure [NYHA (New York Heart Association) classes II to IV]. These effects are not attenuated during long term therapy. More significantly, a clinical study demonstrated that enalapril reduces mortality when added to established therapy in patients with severe congestive heart failure (NYHA class IV) refractory to digitalis, diuretics and other vasodilators. Thus, ACE inhibitors such as enalapril offer a significant advance in the treatment of congestive heart failure. Because these drugs improve symptoms in patients with classes II to IV failure, and reduce mortality in patients with severe heart failure, they should be considered as first choice adjuvant therapy when a vasodilator is needed in addition to conventional treatment with digitalis and diuretics. |
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Authors:
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P A Todd; K L Goa |
Publication Detail:
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Type: Clinical Trial; Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 37 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-05-15 Completed Date: 1989-05-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 141-61 Citation Subset: IM |
Affiliation:
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ADIS Drug Information Services, Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Double-Blind Method Enalapril* / administration & dosage, adverse effects, pharmacology, therapeutic use Heart Failure / drug therapy* Humans Random Allocation |
| Chemical | |
Reg. No./Substance:
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75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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