| Emulsion gel beads of calcium pectinate capable of floating on the gastric fluid: effect of some additives, hardening agent or coating on release behavior of metronidazole. | |
| | |
MedLine Citation:
|
PMID: 15734303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Emulsion gel (EMG) beads of calcium pectinate capable of floating in the gastric condition were developed using an emulsion-gelation method and their release properties were investigated. Attempts to modify the drug release were made by applying some additives into the starting solution prior to bead formation, by hardening with glutaraldehyde, and by coating with polymer. The metronidazole-loaded EMG beads were found to float on simulated gastric fluid. Increasing the drug to pectin ratio in the beads slowed the drug release from the conventional and the EMG beads. However, the drug release from these beads was rapid, i.e., about 80% of drug loading released within 20-80 min. The additives (PEG10000, glyceryl monostearate and Eudragit L) had a slight, insignificant, effect on the drug release. Using 2% glutaraldehyde as a hardening agent prolonged the drug release. Coating the beads with Eudragit RL significantly sustained the drug release while the beads remained buoyant. The results suggest that EMG beads are suitable as a carrier for intragastric floating drug delivery and that their release behaviour could be modified by hardening with glutaraldehyde or by coating with Eudragit RL. |
| | |
Authors:
|
Pornsak Sriamornsak; Nartaya Thirawong; Satit Puttipipatkhachorn |
Related Documents
:
|
3825743 - Sustained release of a corticosteroid using polymeric implants. 17303393 - Nanohybrids for controlled antibiotic release in topical applications. 7984383 - Therapeutic drug monitoring in the pediatric intensive care unit. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-01-23 |
Journal Detail:
|
Title: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Volume: 24 ISSN: 0928-0987 ISO Abbreviation: Eur J Pharm Sci Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-02-28 Completed Date: 2005-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9317982 Medline TA: Eur J Pharm Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 363-73 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. pornsak@email.pharm.su.ac.th |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Calcium
/
chemistry*,
pharmacokinetics Delayed-Action Preparations / chemistry, pharmacokinetics Emulsions Gastric Juice* / metabolism Gels Metronidazole / chemistry*, pharmacokinetics Pectins / chemistry*, pharmacokinetics Tablets, Enteric-Coated |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Emulsions; 0/Gels; 0/Pectins; 0/Tablets, Enteric-Coated; 443-48-1/Metronidazole; 7440-70-2/Calcium; 9000-69-5/pectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fast-dissolving mucoadhesive microparticulate delivery system containing piroxicam.
Next Document: Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis usin...