| Emulation of conduction system functions in the hearts of early mammalian embryos. | |
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MedLine Citation:
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PMID: 2255564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The conduction system functions of atrioventricular sequential contractions, atrioventricular delay, and coordination of ventricular contraction were examined in rat embryos at the earliest functional stage of cardiac development (before cardiac looping, n = 6) and shortly after looping (n = 15). Atrioventricular sequential contractions were observed in all embryos, and contractions appeared to originate in the left sinus horn. Atrioventricular delay was present in both prelooped (132 +/- 32 ms) and looped (141 +/- 15 ms) hearts. Before looping, contractions traveled from proximal ventricle to bulbus cordis, a distance of 253 +/- 27 microns, in 72 +/- 22 ms. After looping, contractions crossed an increased intraventricular distance (520 +/- 28 microns, p less than 0.005) in substantially less time (16 +/- 7 ms, p less than 0.005). Sinoatrial and atrioventricular nodal functions are emulated in both prelooped and looped hearts of early mammalian embryos, and His-Purkinje system function is emulated in looped hearts. |
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Authors:
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T R Lloyd; H S Baldwin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 28 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-01-24 Completed Date: 1991-01-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 425-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics (Cardiology), University of Arizona College of Medicine, Tucson 85724. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Function Fetal Heart / embryology, physiology* Heart Atria / embryology Heart Conduction System / embryology, physiology* Heart Ventricles / embryology Myocardial Contraction / physiology Organ Culture Techniques Rats Rats, Inbred Strains Ventricular Function |
| Grant Support | |
ID/Acronym/Agency:
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HL02917/HL/NHLBI NIH HHS; HL43600/HL/NHLBI NIH HHS; HL67413/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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