| Emu Model of Full-range Femoral Head Osteonecrosis Induced Focally by an Alternating Freezing and Heating Insult. | |
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MedLine Citation:
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PMID: 21672321 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The emu, a large bipedal bird with hip joint biomechanics similar to humans, was used to establish an experimental model of femoral head osteonecrosis and subsequent femoral head collapse. Focal lesions were induced in 20 adult male emus using an alternating liquid nitrogen freezing and radiofrequency heating insult. At 2, 4, 8, 12 and 16 weeks post-surgery, hip magnetic resonance imaging (MRI) was performed. Before the emus were sacrificed, barium sulphate was infused to the lower extremity to study blood vessel distribution patterns. Femoral samples were scanned by micro-computed tomography (micro-CT) and evaluated histologically. Hip MRI showed changes from broad oedema to femoral head collapse. Emus developed a crippled gait from post-operative week 6. Micro-CT scans and histology showed human-like osteonecrotic changes with an impaired local blood supply. The protocol resulted in consistent full-range osteonecrosis of the femoral head that may serve as a model for testing potential treatments. |
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Authors:
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M Fan; J Peng; A Wang; L Zhang; B Liu; Z Ren; W Xu; J Sun; Lx Xu; D Xiao; L Qin; S Lu; Y Wang; Q Y Guo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 39 ISSN: 1473-2300 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 187-98 Citation Subset: IM |
Affiliation:
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Orthopaedic Research Institute, General Hospital of Chinese People's Liberation Army, Beijing, China; Medical College, NanKai University, Tianjin, China, Medical College, NanKai University, Tianjin, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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