Document Detail


Empty sella and primary autoimmune hypothyroidism.
MedLine Citation:
PMID:  19823763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated by our Endocrinology Department. Subjects with a known etiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A total of 56 subjects were included in the study. ES was diagnosed by pituitary MRI. The measurement of free T4, TSH, and antithyroid antibodies (TPOAb and TgAb) was assayed using commercial kits. The cases of hypothyroidism obtained were compared with those in another group of similar patients, diagnosed with diabetes mellitus type 2, through chi2 test. A total of 15 (26.78%) patients of 56 with ES had autoimmune thyroid disease (subclinical or clinical hypothyroidism). Primary hypothyroidism with negative antithyroid autoantibodies was found in a further 13 patients (23.21%). The 46.42% of ES had primary hypothyroidism; this result had obtained a statistically significant difference when compared to the ratio obtained in the group of diabetes mellitus type 2 (P < 0.0029). There is an important association between ES and autoimmune thyroid disease, which reached 26.78% in our series. We suggest the possibility of a common pathogenesis for certain cases of ES and autoimmune thyroid disease, with the end point of ES in the pituitary, and atrophy in the thyroid gland.
Authors:
Rogelio García-Centeno; José Pablo Suárez-Llanos; Elisa Fernández-Fernández; Victor Andía-Melero; Petra Sánchez; Antonino Jara-Albarrán
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Publication Detail:
Type:  Journal Article     Date:  2009-10-01
Journal Detail:
Title:  Clinical and experimental medicine     Volume:  10     ISSN:  1591-9528     ISO Abbreviation:  Clin. Exp. Med.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973405     Medline TA:  Clin Exp Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Hospital General Universitario Gregorio Marañón, Avenida Doctor Esquerdo, 46, 28007 Madrid, Spain. roges82@msn.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Autoantibodies / blood
Autoimmune Diseases / epidemiology*
Comorbidity
Empty Sella Syndrome / epidemiology*
Female
Humans
Hypothyroidism / epidemiology*
Magnetic Resonance Imaging
Male
Middle Aged
Retrospective Studies
Sella Turcica / radiography
Thyrotropin / blood
Thyroxine / blood
Chemical
Reg. No./Substance:
0/Autoantibodies; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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