Document Detail

Empirical trials in treatment of gastroesophageal reflux disease.
MedLine Citation:
PMID:  10729734     Owner:  NLM     Status:  MEDLINE    
The assortment of diagnostic tests that are currently available for detecting gastroesophageal reflux disease (GERD) are invasive, costly and not readily available to community-based physicians. In contrast, a short course of high-dose proton pump inhibitor (PPI) as an empirical trial is an attractive alternative. This simple diagnostic test has been demonstrated to be accurate and cost-effective in patients with symptoms suggestive of GERD and those with noncardiac chest pain. Early studies in patients with extraesophageal manifestations of GERD have yielded promising results. Cost assessment of the PPI empirical trial revealed significant cost savings, mainly due to a marked decrease in utilization of invasive diagnostic tests. Thus the PPI empirical trial should be considered as the initial diagnostic step in patients with the disease spectrum of GERD.
R Fass
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  18     ISSN:  0257-2753     ISO Abbreviation:  Dig Dis     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-08     Completed Date:  2000-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Medicine, Section of Gastroenterology, Southern Arizona V.A. Halth Care System and University of Arizona Health Sciences Center, Tucson, AZ 85273, USA.
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MeSH Terms
Chest Pain / diagnosis,  drug therapy,  etiology
Clinical Trials as Topic* / economics
Cost-Benefit Analysis
Diagnosis, Differential
Enzyme Inhibitors / therapeutic use*
Evaluation Studies as Topic
Gastroesophageal Reflux / complications,  diagnosis,  drug therapy*
Omeprazole / therapeutic use*
Proton Pumps / antagonists & inhibitors*
Reproducibility of Results
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Proton Pumps; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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