Document Detail

Empirical identification and validation of eating disorder phenotypes in a multisite clinical sample.
MedLine Citation:
PMID:  19155809     Owner:  NLM     Status:  MEDLINE    
Identified problems with the classification system of eating disorders (EDs), including its imperfect application to clinical samples, challenge its validity and limit its utility. The present study aimed to empirically identify and validate ED phenotypes in a multisite clinical sample using latent profile analysis (LPA). ED symptom data collected from 687 individuals were included in LPA. Identified latent profiles (LPs) were compared on clinical validators. Five LPs were identified: LP1 (n = 178), objective bingeing and multiple purging methods; LP2 (n = 172), objective bingeing without purging; LP3 (n = 130), objective bingeing and vomiting; LP4 (n = 108), low/normal weight and excessive exercise; LP5 (n = 99), low/normal weight and absence of ED symptoms. Validation analyses demonstrated the most extreme psychopathology/medical morbidity in LP1 and the least in LP5. LP1 and LP3 were most likely to report medication treatment for EDs. Identified LPs imperfectly resembled diagnostic and statistical manual of mental disorders-IV-TR EDs. Multiple purging methods and the absence of ED cognitions marked differences in severity across groups, whereas low weight did not. Clinical differences in psychopathology, medical morbidity, and treatment utilization validated groups. Future research should examine longitudinal stability of empirically-derived phenotypes and incremental validity of alternative classification schema to inform DSM-V.
Kamryn T Eddy; Ross D Crosby; Pamela K Keel; Stephen A Wonderlich; Daniel le Grange; Laura Hill; Pauline Powers; James E Mitchell
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Publication Detail:
Type:  Journal Article; Multicenter Study; Validation Studies    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  197     ISSN:  1539-736X     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnostic and Statistical Manual of Mental Disorders
Diuretics / administration & dosage
Eating Disorders / diagnosis,  physiopathology*,  psychology*
Laxatives / administration & dosage
Severity of Illness Index
Young Adult
Reg. No./Substance:
0/Diuretics; 0/Laxatives

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