| Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development. | |
| | |
MedLine Citation:
|
PMID: 21212527 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The unbound serum concentration of valproic acid (VPA) is closely related to its therapeutic efficacy. In epileptic infants, the unbound VPA concentration varies largely from patient to patient, being difficult to predict using the reported equations for older children. To establish an equation to estimate the unbound concentration in infants, we empirically characterized the relationship between total and unbound VPA concentrations, taking their growth and development into consideration. Data were retrospectively collected from archived clinical records of 30 epileptic infants aged 0-11 months old. The relationship between total and unbound VPA concentrations was analyzed according to the Langmuir equation, in which the patient's body weight, height, and body surface area were considered as physical development indices. Inter- and intra-individual variabilities in the VPA concentrations were also considered. It was shown that the unbound VPA concentration in infants is properly estimated when their body weights are taken into account, in which the parameter for the maximum binding site concentration (Bm) increases as the body weight increases, while that for the dissociation constant (Kd) is unaltered. Additionally, the relationship was shown to slightly change when the infants are concomitantly treated with VPA and the other antiepileptics. These findings provide useful information to adjust the VPA dosage to achieve optimal therapeutic efficacy in epileptic infants. |
| | |
Authors:
|
Satoshi Ueshima; Tetsuya Aiba; Tomoaki Sato; Hisashi Matsunaga; Yuji Kurosaki; Yoko Ohtsuka; Toshiaki Sendo |
Related Documents
:
|
15259037 - Epidemiologic characteristics of anotia and microtia in california, 1989-1997. 6235617 - Epidemiological study of gastroschisis and omphalocele in spain. 11883537 - Postnatal outcome of fetuses with the prenatal diagnosis of gastroschisis. 6540597 - The radiology of stillbirths and neonatal deaths. 3642157 - Anterior cricoid split: the chicago experience with an alternative to tracheotomy. 15259037 - Epidemiologic characteristics of anotia and microtia in california, 1989-1997. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biological & pharmaceutical bulletin Volume: 34 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
|
Languages: eng Pagination: 108-13 Citation Subset: IM |
Affiliation:
|
Department of Hospital Pharmacy, Okayama University Hospital, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active comp...
Next Document: Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in pat...