| Empiric use of trimethoprim-sulfamethoxazole (TMP-SMX) in the treatment of women with uncomplicated urinary tract infections, in a geographical area with a high prevalence of TMP-SMX-resistant uropathogens. | |
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MedLine Citation:
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PMID: 11941541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated whether trimethoprim-sulfamethoxazole (TMP-SMX) is effective for treatment of uncomplicated urinary tract infections (UTIs) due to TMP-SMX-resistant (TMP-SMX-R) pathogens. Healthy nonpregnant premenopausal women with symptomatic lower UTI were assessed for the presence of pyuria and bacteriuria; if either was present, a urine sample was cultured and TMP-SMX was prescribed. Clinical and microbiologic cure was assessed at days 5-9 and 28-42 after cessation of therapy. For 71%, of patients, cultures grew TMP-SMX-susceptible (TMP-SMX-S) microorganisms, and for 29%, cultures grew TMP-SMX-R organisms. Escherichia coli remained the predominant bacteria in both groups of cultures. At visit 2, microbiological cure had been achieved in 86% of the patients in the TMP-SMX-S group and 42% of those in the TMP-SMX-R group. Similar differences were found at visit 3 by clinical evaluation. Treatment with TMP-SMX of uncomplicated UTI caused by TMP-SMX-R microorganisms results in microbiologic and clinical failure. In high-resistance areas, TMP-SMX should not be the empiric drug of choice for uncomplicated UTI. |
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Authors:
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R Raz; B Chazan; Y Kennes; R Colodner; E Rottensterich; M Dan; I Lavi; W Stamm; |
Publication Detail:
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Type: Journal Article Date: 2002-04-04 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 34 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-09 Completed Date: 2002-04-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1165-9 Citation Subset: IM |
Affiliation:
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Infectious Diseases Unit, Haemek Medical Center, Afula; and Technion, Institute of Technology, Haifa, Israel. raz_r@clalit.org.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents, Urinary / therapeutic use* Cystitis / drug therapy Drug Resistance, Bacterial / genetics Female Gene Frequency Humans Middle Aged Premenopause Trimethoprim-Sulfamethoxazole Combination / therapeutic use* Urinary Tract Infections / drug therapy* Women |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Urinary; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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