Document Detail

Emphysematous cystitis in a chemically-induced diabetic dog.
MedLine Citation:
PMID:  22272004     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Emphysematous cystitis is a rare disorder caused by bacterial infection and characterized by gas accumulation within the bladder wall with cyst formation. This report describes the histopathological characteristics of emphysematous cystitis found in a diabetic female beagle induced by streptozotocin and alloxan. Macroscopically, multiple cyst-like structures were observed on the cut surface of the urinary mucosa. During fixation, small specimens cut from the mucosa floated on the surface of the fixative solution. Histopathologically, multiple cysts were lined with a single layer of flattened cells found to be immunohistochemically positive for vimentin, partially positive for α-smooth muscle actin or macrophage scavenger receptor, class A, and thought to be myofibroblasts, fibroblasts or macrophages. Multinucleated giant cells were observed around the cysts, and gram-negative short bacilli were observed in the lumen of the urinary bladder. From these findings, this case was diagnosed as emphysematous cystitis.
Saori Matsuo; Shuji Hayashi; Takeshi Watanabe; Kenji Adachi; Akio Miyoshi; Atsuhiko Kato; Masami Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2009-12-21
Journal Detail:
Title:  Journal of toxicologic pathology     Volume:  22     ISSN:  0914-9198     ISO Abbreviation:  J Toxicol Pathol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9306408     Medline TA:  J Toxicol Pathol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  -    
Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba-shi, Shizuoka 412-8513, Japan.
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