Document Detail

Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  20102378     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Limited data are available on the association between the severity of emphysema or airway narrowing, and health-related quality of life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD), which has been seen to be more prevalent among elderly subjects. The aim of this study was to examine the association between HRQOL, physical parameters and structural alterations in lung of COPD patients. METHODS: Stable COPD patients (n = 125; mean age 71.0) were studied. Both the severity of emphysema, which was expressed as the extent of the low-attenuation area (LAA%), and percentage of the large airway wall area (WA%) on high-resolution computed tomography (HRCT) were compared with various parameters of the generic and HRQOL, respectively, together with pulmonary function tests and exercise capacity. RESULTS: The predicted value of forced expiratory volume in 1 s was significantly associated with both LAA% and WA%, but the diffusion capacity was strongly correlated with LAA% alone. Parameters of the generic and HRQOL, and almost all other parameters appeared to be significantly associated with LAA% alone, whereas no association was observed between WA% and QOL. CONCLUSION: We concluded that the severity of emphysema, but not that of large airway narrowing on HRCT, is associated with both generic and health-related QOL and reduced diffusion capacity. This notion might provide useful information in practice among elderly subjects who are unable to perform a spirometry.
Norihisa Motohashi; Kazuyoshi Kimura; Takeo Ishii; Ritsuko Wakabayashi; Hiroko Kurosaki; Takashi Motegi; Kouichi Yamada; Rupert C M Jones; Akihiko Gemma; Kozui Kida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  10     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Department of Pulmonary Medicine, Infection and Oncology, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Pulmonary Disease, Chronic Obstructive / complications,  radiography*
Pulmonary Emphysema / complications,  radiography*
Quality of Life*
Respiratory Function Tests
Tomography, Spiral Computed

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